Zhong Nanshan’s team developed a new version of Isatis indigotica which may be five or six times stronger than the original
On October 19, sponsored by the China Healthcare International Exchange Promotion Association and hosted by the First Affiliated Hospital of Sun Yat-sen University, the 2019 China Academician Forum was antiqued in Guangzhou, focusing on the theme of “Great Health in the Greater Bay Area”.Gu Xiaosong made separate reports.
In an interview with the media, Zhong Nanshan found that he is planning to expand research on the use of Chinese medicine for influenza prevention, and strive to find another way besides preventive measures such as vaccines.
Talking about flu prevention “Guangdong, Hong Kong, Macao Greater Bay Area is densely populated, and flu is always a topic of interest”.
“Zhong Nanshan said,” Early this year and in July, a small flu peak occurred in our province. By the end of the year, we will spread the climate change and it may become epidemic again.
From a conventional point of view, the epidemic period in the south is generally January-February, so we should be more vigilant. ”
To prevent influenza, Zhong Nanshan said that vaccination is still the best way, but due to lack of publicity and insufficient domestic vaccine production, only 2% of the population has been vaccinated against influenza.
”Can flu prevention find another way?
“Zhong Nanshan revealed that the team is currently cooperating with scientific research units in Hong Kong and plans to study the role of preventive oral administration of Chinese medicine in the response to influenza through strict controlled experiments.
“It is theoretically possible for Chinese medicine to prevent influenza, and some people are also using it empirically. All we have to do is to verify whether it is really effective with scientific methods.
The new technology of Banlangen Banlangen granules is a traditional Chinese medicine granule for clearing heat and detoxifying.
Academician Zhong Nanshan introduced the Banlangen “secondary development”
project jointly carried out by Guangzhou Baiyunshan Hutchison Whampoa Traditional Chinese Medicine Co., Ltd., the State Key Laboratory of Respiratory Diseases of Guangzhou Medical University and the State Key Laboratory of Chinese Medicine Quality Research of Macau University of Science and Technology.
He said that the project has been completed for nearly 10 years. At present, it is clear that there are four main components in which Radix Isatidis play a role, namely sterols, lignans, dioxazoles, and polyvalents.
They function differently, and some have a mild virus killing effect, but more are preventing the virus from entering cells or inhibiting the development of inflammation.
Academician Zhong Nanshan led the research on the secondary development of Banlangen in Baiyun Mountain. “The secondary development of Banlangen according to the new process is currently nearing completion of the medicinal effect study. The oral dose has been reduced by 80%. Animal experiments have shown that the effect is five or six times stronger.
“Zhong Nanshan said that the new drug still has to undergo clinical trials and approvals, and the time to market is uncertain.
Zhong Nanshan believes that purifying and “secondary development” of Banlangen is one of the important ways of modernizing Chinese medicine.
“All science is developing, and the foundation of traditional Chinese medicine is still empirical medicine. To modernize traditional Chinese medicine, we must first develop in the direction of evidence-based medicine. This road must be taken.”
Since 2008, Guangzhou Baiyunshan Hutchison Whampoa Traditional Chinese Medicine Co., Ltd. and the State Key Laboratory of Respiratory Diseases of Guangzhou Medical University and the State Key Laboratory of Traditional Chinese Medicine Quality Research of Macao University of Science and Technology have jointly tackled many problems and conducted a large number of clinical evidence-based andbasic research.
In 2010, Bai Yunshan and Huang, Academician Zhong Nanshan and the Macau University of Science and Technology established the “Guangdong-Macao Respiratory Pathogens Joint Research Center”.
In 2015, Guangzhou Pharmaceutical Group signed a strategic cooperation agreement with the Guangdong-Australia Chinese Medicine Technology Industrial Park and the Macau University of Science and Technology, becoming the first famous enterprise in the park to enter the Guangdong-Macao Traditional Chinese Medicine Technology Industrial Park. This is the “Guangdong-Australia Cooperation Framework Agreement””” The first landing project.
At the 2016 “Guangdong-Hong Kong-Macao Chinese Medicine Banlangen Research Forum and Baiyunshan Banlangen Secondary Development Research Launching Ceremony”, well-known experts and researchers from the Macau University of Science and Technology, Hong Kong University and other units conducted basic and clinical research on the antiviral activity of Baiyunshan Banlangen.Sexual summary.
By complementing the advantages at the above levels, we will work together to promote the modernization and internationalization of Chinese medicine.
Academician Zhong Nanshan and Academician Huang Luqi discussed and answered on-site research on Baiyunshan Banlangen on the Nobel Prize Zhong Nanshan also faced the Nobel Prize in Physiology or Medicine recently announced.
He believes that China is currently estimated to have scientific development with both potential research talents and redundant budgets and venue guarantees. “It is a matter of time before more Chinese people get the Nobel Prize.
However, he also reminded that in the scientific research work, we must properly overcome the impetuous ideas that are eager to achieve success and blindly pursue quick results, and we should create an environment for scholars to feel comfortable and force scientific research.
In addition, we need to further study the transformation of results to make more results truly effective.
Research progress on Banlangen particles in Baiyunshan Academician Zhong Nanshan After more than ten years of research, 21 compounds were isolated from Banlangen and a variety of anti-influenza virus components were found, including polysaccharides, lignans, and dioxin alkaloids.Class, etc.
And applied for 17 invention patents.
Studies have found that isatis root polysaccharide can inhibit the hemagglutinin activity of influenza virus, that is, by inhibiting the mutation of the virus to human cells, thereby inhibiting the replication of the influenza virus and exerting an antiviral effect; at the same time, it can also inhibit the virus infecting the human body.Systemic arthritis response.
This research achievement has successfully applied for a patent, and in 2017 won the “19th China Patent Excellence Award”.
In Isatis indigotica, a lignan anti-influenza virus compound is clematis nebulin B. It can interfere with the expression of a certain protein of the influenza virus and inhibit the growth and reproduction of the virus. Therefore, it can inhibit a variety of human influenza and avian influenza viruses.Role of Subtype Influenza Virus.
Another lignan component is larchesterol-4-O-β-D-glucoside, which inhibits the activation of influenza virus-induced antibacterial factors and exerts an inhibitory effect on the systemic inflammatory response caused by the influenza virus, so it can regulate the human body.Innate immunity.
Studies have not found that the naphthoquinone alkaloid compound-CapparilosideA has inhibitory effects on various subtypes of influenza viruses and other common respiratory viruses, showing broad-spectrum antiviral efficacy.
Experiments show that this dioxin alkaloid can inhibit the inflammatory response caused by the influenza virus and can effectively alleviate the lung damage caused by the influenza virus.
The other is 3-naphthyl butyraldehyde, which shows more broad-spectrum antiviral activity (including A / B human influenza virus, avian influenza virus, common respiratory viruses such as parainfluenza virus, rhinovirus, etc., and potentialVirus, herpes virus, etc.) and stronger anti-flu activity in vitro and in vivo.
(Some sources of the article: People’s Daily, Nanfang Daily) This article only represents the views of the author, and does not represent the views of the old Chinese medicine health network. If copyright issues are involved, please contact the administrator to delete!